Blood Could Be the Key to Unlocking Reversal of Aging

A recent study published in Cell Metabolism reveals that biological aging is fluid rather than fixed. Using a heterochronic parabiosis mouse model, researchers demonstrated that young mice exposed to old blood aged faster, but this effect reversed when the old blood was removed. They measured biological age through DNA methylation clocks, which reflect environmental and experiential influences on DNA over time. The study indicates that stress can accelerate aging, while recovery from stress can decelerate it, a finding observed in both mice and human cohorts experiencing chronic illness, surgery, or pregnancy. During a traumatic incident like hip fractures, biological age markers increased significantly within 24 hours but dropped upon recovery. Conversely, elective surgeries showed no significant aging effects. The study also noted accelerated aging in COVID-19 patients during hospitalization. Researchers now aim to explore what triggers these variations in aging rates and whether factors like mental health also influence biological aging. The findings suggest a potential for reversing aging under certain conditions, challenging the conventional view that aging is solely dictated by time. The next steps will involve understanding how both physical and psychological factors contribute to the acceleration or deceleration of biological aging.

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