RESORT Introduces Revolutionary Living Systems Like Never Before

Researchers from the University of Tokyo have introduced a novel imaging technique called RESORT, which merges super-resolution fluorescence and vibrational imaging through the use of laser-based Raman scattering. This method allows for high spatial resolution imaging without causing damage to biological samples, making it particularly effective for observing living systems in fine detail. RESORT improves upon traditional imaging methods, such as stimulated Raman scattering (SRS), by offering sharper images that aid in identifying cellular components like mitochondria.

The RESORT process begins by tagging biological samples with photoswitchable Raman probes, followed by the application of two-color infrared laser pulses and other light sources to precisely control where Raman scattering occurs. This innovative approach overcomes limitations associated with both super-resolution fluorescence and vibrational imaging, while avoiding the sample damage typically seen in electron microscopy.

Professor Yasuyuki Ozeki, leading the research team, envisions that RESORT will enhance our understanding of biological processes, disease mechanisms, and potential therapies by enabling the observation of multiple cellular constituents simultaneously. Beyond medical research, advancements in RESORT's laser design could also benefit various fields, including materials science.



https://instegro.net/resort-introduces-revolutionary-living-systems-like-never-before/?fsp_sid=82183